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Hyperfunction of pituitary gland, other and/or unspecified

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E4_HYPERPITNAS

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E22.9
  • Hospital discharge: ICD-9 — 2531X
  • Hospital discharge: ICD-8 — 25301
  • Cause of death: ICD-10 — E22.9
  • Cause of death: ICD-9 — 2531X
  • Cause of death: ICD-8 — 25301

2 out of 7 registries used, show all original rules.

53

4. Check minimum number of events

None

53

5. Include endpoints

None

53

6. Filter based on genotype QC (FinnGen only)

53

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 E22
Name in latin Hyperfunctio hypophysis non specificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 363 231 131
Only index persons 324 212 112
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 46.68 44.04 51.12
Only index persons 45.20 41.70 51.83

-FinnGen-

Key figures

All Female Male
Number of individuals 53 34 19
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 50.17 46.22 57.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_HYPERPITNAS – Hyperfunction of pituitary gland, other and/or unspecified

GWS hits: -

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