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Tuberculosis

DOID EFO Endpoint Browser PheWeb

AB1_TUBERCULOSIS

obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A15-A19
  • Hospital discharge: ICD-9 — 01[0-8]
  • Hospital discharge: ICD-8 — 01[0-8]
  • Cause of death: ICD-10 — A15-A19
  • Cause of death: ICD-9 — 01[0-8]
  • Cause of death: ICD-8 — 01[0-8]

2 out of 7 registries used, show all original rules.

2660

4. Check minimum number of events

None

2660

5. Include endpoints

2739

6. Filter based on genotype QC (FinnGen only)

2613

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 48519 21137 25875
Only index persons 25041 12800 12241
Unadjusted period prevalence (%)
Whole population 0.70 0.61 0.72
Only index persons 0.47 0.47 0.47
Median age at first event (years)
Whole population 53.53 53.62 53.34
Only index persons 44.14 44.42 43.83

-FinnGen-

Key figures

All Female Male
Number of individuals 2613 980 1633
Unadjusted period prevalence (%) 0.72 0.43 0.90
Median age at first event (years) 46.83 39.42 51.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: AB1_TUBERCULOSIS – Tuberculosis

GWS hits: 1

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