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Tuberculosis

DOID Endpoint Browser

TUBERCULOSIS

obsolete_tuberculosis: ['A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004', 'Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A15, A16, A19, B90.9
  • Hospital discharge: ICD-9 — 01[1-2]|018
  • Hospital discharge: ICD-8 — 01[1-2]|018
  • Cause of death: ICD-10 — A15, A16, A19, B90.9
  • Cause of death: ICD-9 — 01[1-2]|018
  • Cause of death: ICD-8 — 01[1-2]|018

2 out of 7 registries used, show all original rules.

2345

4. Check minimum number of events

None

2345

5. Include endpoints

None

2345

6. Filter based on genotype QC (FinnGen only)

2244

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Tuberculosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 2244 763 1481
Unadjusted period prevalence (%) 0.65 0.33 0.81
Median age at first event (years) 50.49 41.73 55.00

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: TUBERCULOSIS – Tuberculosis

GWS hits: -

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