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Type 2 diabetes, wide definition

DOID EFO Endpoint Browser PheWeb

T2D_WIDE

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • not PANCREATITIS
422219

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E11
  • Hospital discharge: ICD-9 — 250.A
  • Cause of death: ICD-10 — E11
  • Cause of death: ICD-9 — 250.A

2 out of 7 registries used, show all original rules.

44251

4. Check minimum number of events

None

44251

5. Include endpoints

None

44251

6. Filter based on genotype QC (FinnGen only)

42593

Control definitions (FinnGen only)

Control exclude T2D
Control conditions not PANCREATITIS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 467928 222070 240592
Only index persons 355717 165583 190134
Unadjusted period prevalence (%)
Whole population 6.54 6.36 6.72
Only index persons 6.71 6.09 7.26
Median age at first event (years)
Whole population 68.98 71.95 66.24
Only index persons 67.56 70.26 65.21

-FinnGen-

Key figures

All Female Male
Number of individuals 42593 17438 25155
Unadjusted period prevalence (%) 11.27 7.57 13.84
Median age at first event (years) 64.57 63.69 65.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition

GWS hits: 154

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