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Aortic arch syndrome [Takayasu]

M13_TAKAYASU

Takayasu arteritis: Takayasu arteritis (TAK) is a rare inflammatory large-vessel vasculitis primarily affecting the aorta and its major branches, but also other large vessels, causing stenosis, occlusion, or aneurysm.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M31.4
  • Hospital discharge: ICD-9 4467
  • Cause of death: ICD-10 M31.4
  • Cause of death: ICD-9 4467

2 out of 7 registries used, show all original rules.

51

4. Check minimum number of events

None

51

5. Include endpoints

None

51

6. Filter based on genotype QC (FinnGen only)

49

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M31
Name in latin Syndroma arcus aortae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 358 271 81
Only index persons 287 221 66
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 55.89 56.33 53.98
Only index persons 54.26 55.37 50.54

-FinnGen-

Key figures

All Female Male
Number of individuals 49 37 12
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 47.20 49.27 40.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: M13_TAKAYASU – Aortic arch syndrome [Takayasu]

GWS hits: -

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