Spondylopathies

M13_SPONDYLOPATHY

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M45-M49 Cause of death: ICD-10 — M45-M49 2 out of 7 registries used, show all original rules.	41083
4. Check minimum number of events None	41083
5. Include endpoints M13_ANKYLOSPON M13_SPINENTHES M13_SACROILIITIS M13_OSTEOMYELVERTEB M13_DISCINFECTION M13_DISCITIS M13_SPONDYLOINFECTION M13_SPONDYLINFLAMNAS M13_SPONDYLOSIS M13_SPINSTENOSIS M13_FORESTIER M13_KISSING M13_SPONDYLOTRAUM M13_FATIGFRACT M13_VERTEBCOLLAPSE M13_SPONDYLOPATHYNAS M13_SPONDYLOPATHINOTH	43316
6. Filter based on genotype QC (FinnGen only)	42066

Control definitions (FinnGen only)

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

NAME	M13_SPONDYLOPATHY
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_ANKYLOSPON\|M13_SPINENTHES\|M13_SACROILIITIS\|M13_OSTEOMYELVERTEB\|M13_DISCINFECTION\|M13_DISCITIS\|M13_SPONDYLOINFECTION\|M13_SPONDYLINFLAMNAS\|M13_SPONDYLOSIS\|M13_SPINSTENOSIS\|M13_FORESTIER\|M13_KISSING\|M13_SPONDYLOTRAUM\|M13_FATIGFRACT\|M13_VERTEBCOLLAPSE\|M13_SPONDYLOPATHYNAS\|M13_SPONDYLOPATHINOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M4[5-9]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M4[5-9]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Spondylopathies based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	367998	193655	171564
Only index persons	317161	172034	145127
Unadjusted period prevalence (%)
Whole population	5.18	5.55	4.79
Only index persons	5.97	6.32	5.54
Median age at first event (years)
Whole population	59.70	61.03	58.17
Only index persons	58.75	60.04	57.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42066	22461	19605
Unadjusted period prevalence (%)	10.23	9.75	10.78
Median age at first event (years)	58.53	57.80	59.37

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Spondylopathies

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Spondylopathies (M13_SPONDYLOPATHY)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints