Disorders of muscles

M13_MUSCLE

myositis: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M60-M63 Cause of death: ICD-10 — M60-M63 2 out of 7 registries used, show all original rules.	2855
4. Check minimum number of events None	2855
5. Include endpoints M13_MYOSITIS M13_MYOSITISOSSIF M13_CALCIOSSIMUSCLE M13_DIASTASIS M13_RUPTUREMUSC M13_INFARCMUSC M13_IMMOBIMUSC M13_MUSCONTRAC M13_MUSCLEATROPH M13_MUSCLESTRAIN M13_MUSCLEDISNAS M13_MUSCLEINOTH	3450
6. Filter based on genotype QC (FinnGen only)	3322

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

NAME	M13_MUSCLE
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_MYOSITIS\|M13_MYOSITISOSSIF\|M13_CALCIOSSIMUSCLE\|M13_DIASTASIS\|M13_RUPTUREMUSC\|M13_INFARCMUSC\|M13_IMMOBIMUSC\|M13_MUSCONTRAC\|M13_MUSCLEATROPH\|M13_MUSCLESTRAIN\|M13_MUSCLEDISNAS\|M13_MUSCLEINOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M6[0-3]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M6[0-3]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Disorders of muscles based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	35104	16282	18568
Only index persons	31565	14997	16568
Unadjusted period prevalence (%)
Whole population	0.49	0.47	0.52
Only index persons	0.59	0.55	0.63
Median age at first event (years)
Whole population	45.67	48.04	43.54
Only index persons	44.75	47.23	42.51

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	3322	1783	1539
Unadjusted period prevalence (%)	0.81	0.77	0.85
Median age at first event (years)	50.86	48.17	53.97

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Disorders of muscles

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Disorders of muscles (M13_MUSCLE)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints