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Other specified/unspecified systemic involvement of connective tissue

DOID EFO Endpoint Browser PheWeb

M13_CONNECTNAS

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M35.8, M35.9
  • Hospital discharge: ICD-9 — 710[8-9]
  • Hospital discharge: ICD-8 — 7349[1-9]
  • Cause of death: ICD-10 — M35.8, M35.9
  • Cause of death: ICD-9 — 710[8-9]
  • Cause of death: ICD-8 — 7349[1-9]

2 out of 7 registries used, show all original rules.

1875

4. Check minimum number of events

None

1875

5. Include endpoints

None

1875

6. Filter based on genotype QC (FinnGen only)

1814

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14013 10660 3215
Only index persons 11603 9189 2414
Unadjusted period prevalence (%)
Whole population 0.25 0.31 0.09
Only index persons 0.29 0.34 0.09
Median age at first event (years)
Whole population 52.98 51.92 56.35
Only index persons 50.88 50.14 53.68

-FinnGen-

Key figures

All Female Male
Number of individuals 1814 1432 382
Unadjusted period prevalence (%) 0.54 0.62 0.21
Median age at first event (years) 50.44 48.94 56.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_CONNECTNAS – Other specified/unspecified systemic involvement of connective tissue

GWS hits: 1

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