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Ulcerative colitis (strict definition, require KELA, min 2 HDR)

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K11_UC_STRICT2

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • K11_KELAUC
  • and K11_ULCERnumber of events
  • >1
6713

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K51
  • Hospital discharge: ICD-9 — 556
  • Hospital discharge: ICD-8 — 5631|569
  • Hospital discharge: excluded ICD-9 — 5564A
  • Cause of death: ICD-10 — K51
  • Cause of death: ICD-9 — 556
  • Cause of death: ICD-8 — 5631|569
  • Cause of death: excluded ICD-9 — 5564A

2 out of 7 registries used, show all original rules.

6106

4. Check minimum number of events

None

6106

5. Include endpoints

None

6106

6. Filter based on genotype QC (FinnGen only)

5931

Control definitions (FinnGen only)

Control conditions not K11_KELAUC

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Colitis ulcerosa

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 41969 18869 22911
Only index persons 39683 18151 21532
Unadjusted period prevalence (%)
Whole population 0.59 0.54 0.64
Only index persons 0.75 0.67 0.82
Median age at first event (years)
Whole population 37.32 36.03 38.27
Only index persons 36.56 35.57 37.40

-FinnGen-

Key figures

All Female Male
Number of individuals 5931 3007 2924
Unadjusted period prevalence (%) 1.45 1.31 1.61
Median age at first event (years) 38.46 34.92 42.11

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: K11_UC_STRICT2 – Ulcerative colitis (strict definition, require KELA, min 2 HDR)

GWS hits: 44

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