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Cholangitis (primary sclerosing, PSC), with reimbursement 202

DOID EFO Endpoint Browser PheWeb

K11_CHOLANGI_STRICT

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • K11_REIMB_202
25177

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K83.0
  • Hospital discharge: ICD-9 — 5761
  • Hospital discharge: ICD-8 — 5750[4-5]
  • Cause of death: ICD-10 — K83.0
  • Cause of death: ICD-9 — 5761
  • Cause of death: ICD-8 — 5750[4-5]

2 out of 7 registries used, show all original rules.

560

4. Check minimum number of events

None

560

5. Include endpoints

None

560

6. Filter based on genotype QC (FinnGen only)

545

Control definitions (FinnGen only)

Control exclude K11_IBD_STRICT_PSC
Control conditions not K11_REIMB_202

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 K83
Name in latin Cholangitis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2699 1491 1192
Only index persons 2473 1364 1109
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.03
Only index persons 0.05 0.05 0.04
Median age at first event (years)
Whole population 52.12 57.80 44.91
Only index persons 50.38 56.59 42.74

-FinnGen-

Key figures

All Female Male
Number of individuals 545 299 246
Unadjusted period prevalence (%) 0.13 0.13 0.14
Median age at first event (years) 44.71 48.17 40.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: K11_CHOLANGI_STRICT – Cholangitis (primary sclerosing, PSC), with reimbursement 202

GWS hits: 1

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