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Cholangitis (primary sclerosing, PSC)

DOID EFO Endpoint Browser PheWeb

K11_CHOLANGI

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K83.0
  • Hospital discharge: ICD-9 — 5761
  • Hospital discharge: ICD-8 — 5750[4-5]
  • Cause of death: ICD-10 — K83.0
  • Cause of death: ICD-9 — 5761
  • Cause of death: ICD-8 — 5750[4-5]

2 out of 7 registries used, show all original rules.

1903

4. Check minimum number of events

None

1903

5. Include endpoints

None

1903

6. Filter based on genotype QC (FinnGen only)

1843

Control definitions (FinnGen only)

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K83
Name in latin Cholangitis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17623 8929 8513
Only index persons 14119 7308 6811
Unadjusted period prevalence (%)
Whole population 0.25 0.26 0.24
Only index persons 0.26 0.27 0.26
Median age at first event (years)
Whole population 69.88 71.11 68.55
Only index persons 69.40 70.72 67.98

-FinnGen-

Key figures

All Female Male
Number of individuals 1843 864 979
Unadjusted period prevalence (%) 0.46 0.38 0.54
Median age at first event (years) 61.87 57.42 65.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)

GWS hits: 1

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