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Crohn disease (strict definition, require KELA, min 2 HDR)

DOID Endpoint Browser PheWeb

K11_CD_STRICT2

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • K11_KELACROHN
  • and K11_CROHNnumber of events
  • >1
2281

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K50
  • Hospital discharge: ICD-9 — 555
  • Hospital discharge: ICD-8 — 5630
  • Cause of death: ICD-10 — K50
  • Cause of death: ICD-9 — 555
  • Cause of death: ICD-8 — 5630

2 out of 7 registries used, show all original rules.

2109

4. Check minimum number of events

None

2109

5. Include endpoints

None

2109

6. Filter based on genotype QC (FinnGen only)

2033

Control definitions (FinnGen only)

Control conditions not K11_KELACROHN

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12555 6354 6153
Only index persons 12138 6175 5963
Unadjusted period prevalence (%)
Whole population 0.18 0.18 0.17
Only index persons 0.23 0.23 0.23
Median age at first event (years)
Whole population 35.44 35.86 34.99
Only index persons 35.17 35.59 34.74

-FinnGen-

Key figures

All Female Male
Number of individuals 2033 1172 861
Unadjusted period prevalence (%) 0.49 0.51 0.47
Median age at first event (years) 38.63 37.45 40.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: K11_CD_STRICT2 – Crohn disease (strict definition, require KELA, min 2 HDR)

GWS hits: 9

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