Myocardial infarction, strict

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Main diagnosis only: side diagnoses are not checked.

Registry filters:

  • Hospital discharge: ICD-10 I21, I22
  • Hospital discharge: ICD-9 410
  • Hospital discharge: ICD-8 410
  • Hospital discharge: excluded ICD-10 I21.90, I21.97, I22.90, I22.97
  • Cause of death: ICD-10 I21, I22
  • Cause of death: ICD-9 410
  • Cause of death: ICD-8 410
  • Cause of death: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

2 out of 7 registries used, show all original rules.

27016

4. Check minimum number of events

None

27016

5. Include endpoints

None

27016

6. Filter based on genotype QC (FinnGen only)

26060

Control definitions (FinnGen only)

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 463154 166806 284587
Only index persons 216802 83212 133590
Unadjusted period prevalence (%)
Whole population 6.92 4.78 7.95
Only index persons 4.32 3.06 5.10
Median age at first event (years)
Whole population 69.65 75.90 66.10
Only index persons 69.63 76.53 65.34

-FinnGen-

Key figures

All Female Male
Number of individuals 26060 6715 19345
Unadjusted period prevalence (%) 8.65 2.92 10.64
Median age at first event (years) 67.04 70.45 65.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: I9_MI_STRICT – Myocardial infarction, strict

GWS hits: 55

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