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Ischaemic heart disease, wide definition

DOID EFO Endpoint Browser PheWeb

I9_IHD

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I20-I25
  • Hospital discharge: ICD-9 — 41[0-4]
  • Hospital discharge: ICD-8 — 41[0-4]
  • Cause of death: ICD-10 — I21, I22, I23, I24, I25, I46, R96, R98
  • Cause of death: ICD-9 — 41[0-4]|798
  • Cause of death: ICD-8 — 41[0-4]|798
  • Cause of death: excluded ICD-9 — 7980A
  • KELA reimbursements: KELA codes — 206

3 out of 7 registries used, show all original rules.

71320

4. Check minimum number of events

None

71320

5. Include endpoints

None

71320

6. Filter based on genotype QC (FinnGen only)

69007

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1023060 426636 575441
Only index persons 579760 259579 320181
Unadjusted period prevalence (%)
Whole population 14.59 12.22 16.08
Only index persons 11.02 9.54 12.22
Median age at first event (years)
Whole population 67.45 71.65 64.39
Only index persons 66.40 70.13 63.38

-FinnGen-

Key figures

All Female Male
Number of individuals 69007 23114 45893
Unadjusted period prevalence (%) 20.15 10.04 25.24
Median age at first event (years) 64.23 65.06 63.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_IHD – Ischaemic heart disease, wide definition

GWS hits: 86

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