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Hypertensive Renal Disease

DOID EFO Endpoint Browser PheWeb

I9_HYPTENSRD

nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I12
  • Hospital discharge: ICD-9 — 4039A
  • Hospital discharge: ICD-8 — 40399
  • Cause of death: ICD-10 — I12
  • Cause of death: ICD-9 — 4039A
  • Cause of death: ICD-8 — 40399

2 out of 7 registries used, show all original rules.

1153

4. Check minimum number of events

None

1153

5. Include endpoints

None

1153

6. Filter based on genotype QC (FinnGen only)

1115

Control definitions (FinnGen only)

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I10-I15
Name in latin Morbus hypertensivus renalis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14004 5705 8046
Only index persons 9620 3999 5621
Unadjusted period prevalence (%)
Whole population 0.20 0.16 0.22
Only index persons 0.19 0.15 0.21
Median age at first event (years)
Whole population 70.24 73.64 68.06
Only index persons 72.51 76.08 69.97

-FinnGen-

Key figures

All Female Male
Number of individuals 1115 350 765
Unadjusted period prevalence (%) 0.34 0.15 0.42
Median age at first event (years) 67.46 65.09 68.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_HYPTENSRD – Hypertensive Renal Disease

GWS hits: 1

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