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Cerebral atherosclerosis

DOID EFO Endpoint Browser PheWeb

I9_CEREBATHER

cerebral atherosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I67.2
  • Hospital discharge: ICD-9 — 4370
  • Hospital discharge: ICD-8 — 437
  • Cause of death: ICD-10 — I67.2
  • Cause of death: ICD-9 — 4370
  • Cause of death: ICD-8 — 437

2 out of 7 registries used, show all original rules.

354

4. Check minimum number of events

None

354

5. Include endpoints

None

354

6. Filter based on genotype QC (FinnGen only)

342

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 I67
Name in latin Atherosclerosis cerebralis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13448 6688 6394
Only index persons 3338 1814 1524
Unadjusted period prevalence (%)
Whole population 0.19 0.19 0.18
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 76.04 77.52 74.70
Only index persons 76.30 78.24 74.00

-FinnGen-

Key figures

All Female Male
Number of individuals 342 117 225
Unadjusted period prevalence (%) 0.10 0.05 0.12
Median age at first event (years) 72.72 71.81 73.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_CEREBATHER – Cerebral atherosclerosis

GWS hits: 1

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