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Atrial fibrillation and flutter

DOID EFO Endpoint Browser PheWeb

I9_AF

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I48
  • Hospital discharge: ICD-9 — 4273
  • Hospital discharge: ICD-8 — 42792
  • Cause of death: ICD-10 — I48
  • Cause of death: ICD-9 — 4273
  • Cause of death: ICD-8 — 42792
  • KELA reimbursements: KELA codes — 207|351
  • KELA reimbursements: ICD-10 — I48

3 out of 7 registries used, show all original rules.

52261

4. Check minimum number of events

None

52261

5. Include endpoints

52261

6. Filter based on genotype QC (FinnGen only)

50742

Control definitions (FinnGen only)

Control exclude FG_CVD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Fibrillatio atriorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 604062 286372 311083
Only index persons 464709 222369 242340
Unadjusted period prevalence (%)
Whole population 8.44 8.20 8.69
Only index persons 8.74 8.17 9.25
Median age at first event (years)
Whole population 72.95 76.96 69.29
Only index persons 72.55 76.76 68.69

-FinnGen-

Key figures

All Female Male
Number of individuals 50742 18932 31810
Unadjusted period prevalence (%) 14.04 8.22 17.50
Median age at first event (years) 69.57 71.26 68.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_AF – Atrial fibrillation and flutter

GWS hits: 113

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