Disorders of sclera, cornea, iris and ciliary body

H7_SCLERACORNEA

corneal neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

21489

4. Check minimum number of events

None

21489

5. Include endpoints

22356

6. Filter based on genotype QC (FinnGen only)

21534

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 230055 113677 115074
Only index persons 211242 105198 106044
Unadjusted period prevalence (%)
Whole population 3.22 3.26 3.22
Only index persons 3.96 3.87 4.05
Median age at first event (years)
Whole population 46.12 49.90 42.42
Only index persons 45.36 48.92 41.82

-FinnGen-

Key figures

All Female Male
Number of individuals 21534 12092 9442
Unadjusted period prevalence (%) 5.23 5.25 5.19
Median age at first event (years) 50.02 49.15 51.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: H7_SCLERACORNEA – Disorders of sclera, cornea, iris and ciliary body

GWS hits: 10

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