corneal neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
21489 |
4. Check minimum number of eventsNone |
21489 |
5. Include endpoints |
22356 |
6. Filter based on genotype QC (FinnGen only) |
21534 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of sclera, cornea, iris and ciliary body
based on the number of shared cases.
Broader endpoints:
Narrower endpoints:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 230055 | 113677 | 115074 |
| Only index persons | 211242 | 105198 | 106044 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.22 | 3.26 | 3.22 |
| Only index persons | 3.96 | 3.87 | 4.05 |
| Median age at first event (years) | |||
| Whole population | 46.12 | 49.90 | 42.42 |
| Only index persons | 45.36 | 48.92 | 41.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 21534 | 12092 | 9442 |
| Unadjusted period prevalence (%) | 5.23 | 5.25 | 5.19 |
| Median age at first event (years) | 50.02 | 49.15 | 51.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: H7_SCLERACORNEA – Disorders of sclera, cornea, iris and ciliary body
GWS hits: 10
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