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Migraine

DOID EFO Endpoint Browser PheWeb

G6_MIGRAINE

migraine disorder: A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G43
  • Hospital discharge: ICD-9 — 346
  • Hospital discharge: ICD-8 — 346
  • Hospital discharge: excluded ICD-8 — 34601
  • Cause of death: ICD-10 — G43
  • Cause of death: ICD-9 — 346
  • Cause of death: ICD-8 — 346
  • Cause of death: excluded ICD-8 — 34601

2 out of 7 registries used, show all original rules.

21699

4. Check minimum number of events

None

21699

5. Include endpoints

21699

6. Filter based on genotype QC (FinnGen only)

20908

Control definitions (FinnGen only)

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G40-G47
Name in latin Hemicrania

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 182609 133269 48268
Only index persons 174552 129263 45289
Unadjusted period prevalence (%)
Whole population 3.15 3.82 1.35
Only index persons 3.97 4.75 1.73
Median age at first event (years)
Whole population 32.88 35.07 26.80
Only index persons 33.09 35.03 27.55

-FinnGen-

Key figures

All Female Male
Number of individuals 20908 17285 3623
Unadjusted period prevalence (%) 6.55 7.51 1.99
Median age at first event (years) 39.65 39.03 42.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: G6_MIGRAINE – Migraine

GWS hits: 4

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