Acute alcohol intoxication

F5_ALCOHOLAC

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F10.0
  • Hospital discharge: ICD-9 3050A
  • Hospital discharge: ICD-8 303
  • Cause of death: ICD-10 F10.0
  • Cause of death: ICD-9 3050A
  • Cause of death: ICD-8 303

2 out of 7 registries used, show all original rules.

10170

4. Check minimum number of events

None

10170

5. Include endpoints

None

10170

6. Filter based on genotype QC (FinnGen only)

9884

Control definitions (FinnGen only)

Control exclude F5_SUBSTANCE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F10

Similar endpoints

List of similar endpoints to Acute alcohol intoxication based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 181212 42870 135325
Only index persons 119294 34745 84549
Unadjusted period prevalence (%)
Whole population 3.17 1.23 3.78
Only index persons 2.66 1.28 3.23
Median age at first event (years)
Whole population 42.30 39.98 42.90
Only index persons 40.40 37.72 41.50

-FinnGen-

Key figures

All Female Male
Number of individuals 9884 2962 6922
Unadjusted period prevalence (%) 3.05 1.29 3.81
Median age at first event (years) 43.74 38.17 46.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: F5_ALCOHOLAC – Acute alcohol intoxication

GWS hits: 2

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