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Primary ovarian failure

DOID EFO Endpoint Browser PheWeb

E4_OVARFAIL

primary ovarian insufficiency: Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

only females

239906

2. Check conditions

None

239906

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E28.3
  • Hospital discharge: ICD-9 — 2563
  • Hospital discharge: ICD-8 — 2561
  • Cause of death: ICD-10 — E28.3
  • Cause of death: ICD-9 — 2563
  • Cause of death: ICD-8 — 2561
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — E28.3

3 out of 7 registries used, show all original rules.

580

4. Check minimum number of events

None

580

5. Include endpoints

None

580

6. Filter based on genotype QC (FinnGen only)

542

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E28
Name in latin Insufficientia ovariorum primaria

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2798 2798 -
Only index persons 2690 2690 -
Unadjusted period prevalence (%)
Whole population 0.08 0.08 -
Only index persons 0.10 0.10 -
Median age at first event (years)
Whole population - 36.22 -
Only index persons - 36.17 -

-FinnGen-

Key figures

All Female Male
Number of individuals 542 542 -
Unadjusted period prevalence (%) 0.24 0.24 -
Median age at first event (years) 37.98 37.98 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: E4_OVARFAIL – Primary ovarian failure

GWS hits: 1

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