diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditionsNone |
429209 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1165 |
4. Check minimum number of eventsNone |
1165 |
5. Include endpointsNone |
1165 |
6. Filter based on genotype QC (FinnGen only) |
1139 |
Control definitions (FinnGen only)
Control exclude
E4_DIABETES
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes with neurological complications
based on the number of shared cases.
Broader endpoints:
- Diabetic neuropathy
- Type 1 diabetes
- Nerve, nerve root and plexus disorders
- Diabetes mellitus
- Autoimmune diseases
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7264 | 2794 | 4363 |
| Only index persons | 5456 | 2146 | 3310 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.08 | 0.12 |
| Only index persons | 0.11 | 0.08 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 51.58 | 51.40 | 51.52 |
| Only index persons | 50.20 | 49.16 | 50.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1139 | 517 | 622 |
| Unadjusted period prevalence (%) | 0.29 | 0.22 | 0.34 |
| Median age at first event (years) | 46.93 | 43.72 | 49.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: E4_DM1NEU – Type 1 diabetes with neurological complications
GWS hits: 2
Loading Relationships table