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Diabetic neuropathy

DOID EFO Endpoint Browser PheWeb

DM_NEUROPATHY

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E1[0-4]4
  • Hospital discharge: ICD-9 — 2505
  • Hospital discharge: ICD-8 — 25005
  • Cause of death: ICD-10 — E1[0-4]4
  • Cause of death: ICD-9 — 2505
  • Cause of death: ICD-8 — 25005

2 out of 7 registries used, show all original rules.

3163

4. Check minimum number of events

None

3163

5. Include endpoints

3163

6. Filter based on genotype QC (FinnGen only)

3054

Control definitions (FinnGen only)

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 27892 10554 16871
Only index persons 18681 6578 12103
Unadjusted period prevalence (%)
Whole population 0.41 0.30 0.47
Only index persons 0.38 0.24 0.46
Median age at first event (years)
Whole population 63.80 67.40 61.54
Only index persons 61.95 63.80 60.95

-FinnGen-

Key figures

All Female Male
Number of individuals 3054 1083 1971
Unadjusted period prevalence (%) 0.87 0.47 1.08
Median age at first event (years) 58.35 55.28 60.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: DM_NEUROPATHY – Diabetic neuropathy

GWS hits: 2

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