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Non-follicular lymphoma

DOID EFO Endpoint Browser

CD2_NONFOLLICULAR_LYMPHOMA

neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C83
  • Hospital discharge: ICD-9 — 200
  • Hospital discharge: excluded ICD-9 — 200A
  • Cause of death: ICD-10 — C83
  • Cause of death: ICD-9 — 200
  • Cause of death: excluded ICD-9 — 200A

2 out of 7 registries used, show all original rules.

2907

4. Check minimum number of events

None

2907

5. Include endpoints

None

2907

6. Filter based on genotype QC (FinnGen only)

2811

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 C81-C96
Name in latin Lymphoma non-Hodgkin diffusum

Similar endpoints

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List of similar endpoints to Non-follicular lymphoma based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 2811 1140 1671
Unadjusted period prevalence (%) 0.75 0.50 0.92
Median age at first event (years) 65.71 63.55 67.18

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_NONFOLLICULAR_LYMPHOMA – Non-follicular lymphoma

GWS hits: 1

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