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Diffuse large B-cell lymphoma (controls excluding all cancers)

Endpoint Browser PheWeb

C3_DLBCL_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_DLBCL
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C83.3
  • Cause of death: ICD-9 — 2000B
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 9680
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_DLBCL

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9142 4536 4558
Only index persons 8141 3936 4205
Unadjusted period prevalence (%)
Whole population 0.13 0.13 0.13
Only index persons 0.15 0.14 0.16
Median age at first event (years)
Whole population 70.38 71.49 69.28
Only index persons 70.10 71.16 69.12

-FinnGen-

Key figures

All Female Male
Number of individuals 1050 454 596
Unadjusted period prevalence (%) 0.27 0.20 0.33
Median age at first event (years) 67.13 65.50 68.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: C3_DLBCL_EXALLC – Diffuse large B-cell lymphoma (controls excluding all cancers)

GWS hits: 1

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