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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_DLBCL_EXALLC for full statistics.

Diffuse large B-cell lymphoma

DOID Endpoint Browser

C3_DLBCL

diffuse large B-cell lymphoma: Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • HLP_C3_DLBCL
1077

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C83.3
  • Cause of death: ICD-9 — 2000B
  • Cancer registry: Topography ICD-O-3 — ANY
  • Cancer registry: Morphology ICD-O-3 — 9680
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

1077

4. Check minimum number of events

None

1077

5. Include endpoints

1077

6. Filter based on genotype QC (FinnGen only)

1050

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1050 454 596
Unadjusted period prevalence (%) 0.27 0.20 0.33
Median age at first event (years) 67.13 65.50 68.38

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: C3_DLBCL – Diffuse large B-cell lymphoma

GWS hits: -

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