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Multiple myeloma and malignant plasma cell neoplasms

DOID EFO Endpoint Browser

CD2_MULTIPLE_MYELOMA_PLASMA_CELL

multiple myeloma: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C90
  • Hospital discharge: ICD-9 — 203
  • Hospital discharge: ICD-8 — 203
  • Cause of death: ICD-10 — C90
  • Cause of death: ICD-9 — 203
  • Cause of death: ICD-8 — 203

2 out of 7 registries used, show all original rules.

1394

4. Check minimum number of events

None

1394

5. Include endpoints

None

1394

6. Filter based on genotype QC (FinnGen only)

1337

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF8
Parent code in ICD-10 C81-C96
Name in latin Myeloma multiplex et neoplasmata maligna plasmacytorum

Similar endpoints

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List of similar endpoints to Multiple myeloma and malignant plasma cell neoplasms based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1337 583 754
Unadjusted period prevalence (%) 0.34 0.25 0.41
Median age at first event (years) 68.79 67.66 69.67

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_MULTIPLE_MYELOMA_PLASMA_CELL – Multiple myeloma and malignant plasma cell neoplasms

GWS hits: -

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