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Brain glioblastoma (controls excluding all cancers)

Endpoint Browser PheWeb

C3_GBM_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_GBM
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — 9440
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_GBM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4363 1812 2473
Only index persons 2257 937 1320
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.07
Only index persons 0.04 0.03 0.05
Median age at first event (years)
Whole population 63.71 65.05 62.64
Only index persons 65.60 66.91 64.67

-FinnGen-

Key figures

All Female Male
Number of individuals 253 95 158
Unadjusted period prevalence (%) 0.07 0.04 0.09
Median age at first event (years) 66.08 66.18 66.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: C3_GBM_EXALLC – Brain glioblastoma (controls excluding all cancers)

GWS hits: -

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