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Brain glioblastoma and astrocytoma (controls excluding all cancers)

Endpoint Browser PheWeb

C3_GBM_ASTROCYTOMA_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_GBM
  • or HLP_C3_ASTROCYTOMA
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — 9400|9440
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Similar endpoints

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List of similar endpoints to Brain glioblastoma and astrocytoma (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5422 2291 3041
Only index persons 2896 1237 1659
Unadjusted period prevalence (%)
Whole population 0.08 0.07 0.08
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 61.34 62.28 60.49
Only index persons 62.94 64.06 62.10

-FinnGen-

Key figures

All Female Male
Number of individuals 341 132 209
Unadjusted period prevalence (%) 0.09 0.06 0.11
Median age at first event (years) 63.20 62.27 63.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: C3_GBM_ASTROCYTOMA_EXALLC – Brain glioblastoma and astrocytoma (controls excluding all cancers)

GWS hits: -

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