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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart C3_GBM_EXALLC for full statistics.

Brain glioblastoma

DOID Endpoint Browser

C3_GBM

brain glioblastoma: A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

  • HLP_C3_GBM
273

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — 9440
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

273

4. Check minimum number of events

None

273

5. Include endpoints

273

6. Filter based on genotype QC (FinnGen only)

253

Control definitions (FinnGen only)

Control conditions not HLP_C3_GBM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 253 95 158
Unadjusted period prevalence (%) 0.07 0.04 0.09
Median age at first event (years) 66.08 66.18 66.03

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: C3_GBM – Brain glioblastoma

GWS hits: -

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