asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditions
|
48366 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
25153 |
6. Filter based on genotype QC (FinnGen only) |
24275 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_HOSPITAL_INFECTIONS
Control conditions
not J10_ASTHMA
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to Asthma-related infections based on the number of shared cases.
Broader endpoints:
- Asthma, hospital admission 2, infections
- Asthma (more control exclusions)
- Asthma
- Asthma, including avohilmo
- Chronic lower respiratory diseases
Narrower endpoints:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 296918 | 145717 | 149348 |
Only index persons | 246457 | 124868 | 121589 |
Unadjusted period prevalence (%) | |||
Whole population | 4.16 | 4.17 | 4.17 |
Only index persons | 4.62 | 4.59 | 4.64 |
Median age at first event (years) | |||
Whole population | 34.23 | 48.46 | 19.95 |
Only index persons | 33.15 | 46.08 | 19.86 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 24275 | 13764 | 10511 |
Unadjusted period prevalence (%) | 5.89 | 5.98 | 5.78 |
Median age at first event (years) | 48.32 | 45.72 | 51.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: ASTHMA_INFECTIONS – Asthma-related infections
GWS hits: 26
Loading Relationships table