type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditions
|
907 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
536 |
6. Filter based on genotype QC (FinnGen only) |
515 |
Control definitions (FinnGen only)
Control exclude
DIABETES_FG
Control conditions
not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, wide definition, subgroup 2
based on the number of shared cases.
Broader endpoints:
- Type 1 diabetes, wide definition
- Sub-endpoint used in defining T1D endpoints
- Insulin, fast-acting or short human
- Insulin medication
- Diabetes, insulin treatment (Kela reimbursement)
Narrower endpoints:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8193 | 3476 | 4409 |
| Only index persons | 2249 | 991 | 1258 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.12 |
| Only index persons | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 53.87 | 58.28 | 50.15 |
| Only index persons | 48.96 | 53.50 | 45.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 515 | 215 | 300 |
| Unadjusted period prevalence (%) | 0.14 | 0.09 | 0.17 |
| Median age at first event (years) | 52.64 | 49.89 | 54.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: T1D_WIDE2 – Type 1 diabetes, wide definition, subgroup 2
GWS hits: 1
Loading Relationships table