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Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8 (more control exclusions)

Endpoint Browser PheWeb

O15_ICP_WIDE_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O26.6
  • Hospital discharge: ICD-9 — 6467
  • Hospital discharge: ICD-8 — 6390
  • Cause of death: ICD-10 — O26.6
  • Cause of death: ICD-9 — 6467
  • Cause of death: ICD-8 — 6390

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O26
Name in latin Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Similar endpoints

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List of similar endpoints to Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8 (more control exclusions) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23532 23532 -
Only index persons 23124 23124 -
Unadjusted period prevalence (%)
Whole population 0.67 0.67 -
Only index persons 0.85 0.85 -
Median age at first event (years)
Whole population - 29.44 -
Only index persons - 29.44 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2784 2784 -
Unadjusted period prevalence (%) 1.21 1.21 -
Median age at first event (years) 29.59 29.59 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: O15_ICP_WIDE_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8 (more control exclusions)

GWS hits: 28

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