Intrahepatic Cholestasis of Pregnancy (ICP)  (more control exclusions)

O15_ICP_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O26.6
  • Hospital discharge: ICD-9 6467
  • Cause of death: ICD-10 O26.6
  • Cause of death: ICD-9 6467

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O26
Name in latin Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19565 19565 -
Only index persons 19357 19357 -
Unadjusted period prevalence (%)
Whole population 0.56 0.56 -
Only index persons 0.71 0.71 -
Median age at first event (years)
Whole population - 29.97 -
Only index persons - 29.97 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2257 2257 -
Unadjusted period prevalence (%) 0.98 0.98 -
Median age at first event (years) 30.40 30.40 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: O15_ICP_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP)  (more control exclusions)

GWS hits: 21

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