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Paget disease

DOID EFO Endpoint Browser PheWeb

M13_PAGET

osteitis deformans: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M88
  • Hospital discharge: ICD-9 — 7310
  • Hospital discharge: ICD-8 — 72199
  • Cause of death: ICD-10 — M88
  • Cause of death: ICD-9 — 7310
  • Cause of death: ICD-8 — 72199

2 out of 7 registries used, show all original rules.

136

4. Check minimum number of events

None

136

5. Include endpoints

None

136

6. Filter based on genotype QC (FinnGen only)

133

Control definitions (FinnGen only)

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M86-M90
Name in latin Osteitis deformans Paget

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1125 513 598
Only index persons 891 427 464
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 66.25 66.30 66.15
Only index persons 64.97 63.99 65.87

-FinnGen-

Key figures

All Female Male
Number of individuals 133 53 80
Unadjusted period prevalence (%) 0.04 0.02 0.04
Median age at first event (years) 66.36 66.95 65.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_PAGET – Paget disease

GWS hits: -

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