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Coxarthrosis,

DOID EFO Endpoint Browser PheWeb

M13_ARTHTROSIS_COX

osteoarthritis: A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M16
  • Hospital discharge: ICD-9 — 7151E|7152E
  • Hospital discharge: ICD-8 — 71300
  • Cause of death: ICD-10 — M16
  • Cause of death: ICD-9 — 7151E|7152E
  • Cause of death: ICD-8 — 71300

2 out of 7 registries used, show all original rules.

25018

4. Check minimum number of events

None

25018

5. Include endpoints

None

25018

6. Filter based on genotype QC (FinnGen only)

24254

Control definitions (FinnGen only)

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M15-M19
Name in latin Coxarthrosis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 239771 136898 101259
Only index persons 203723 118143 85580
Unadjusted period prevalence (%)
Whole population 3.44 3.92 2.83
Only index persons 3.89 4.34 3.27
Median age at first event (years)
Whole population 67.48 68.83 65.65
Only index persons 66.79 68.21 64.83

-FinnGen-

Key figures

All Female Male
Number of individuals 24254 12962 11292
Unadjusted period prevalence (%) 5.90 5.63 6.21
Median age at first event (years) 65.09 64.77 65.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: M13_ARTHTROSIS_COX – Coxarthrosis,

GWS hits: 59

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