ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
429209 |
1. Apply sex-specific ruleNone |
429209 |
2. Check conditions
|
3059 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
1438 |
4. Check minimum number of eventsNone |
1438 |
5. Include endpointsNone |
1438 |
6. Filter based on genotype QC (FinnGen only) |
1381 |
Control definitions (FinnGen only)
Control conditions
not M13_ANKYLOSPON_ICD10
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Ankylosing spondylitis, strict definition
based on the number of shared cases.
Broader endpoints:
- Ankylosing spondylitis, ICD10
- Ankylosing spondylitis
- Spondylopathies (FG)
- Spondyloarthritis
- Autoimmune diseases related-to ILD
Narrower endpoints:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8672 | 3328 | 5319 |
| Only index persons | 8532 | 3302 | 5230 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.10 | 0.15 |
| Only index persons | 0.17 | 0.12 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 37.75 | 38.28 | 37.43 |
| Only index persons | 37.70 | 38.29 | 37.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1381 | 643 | 738 |
| Unadjusted period prevalence (%) | 0.35 | 0.28 | 0.41 |
| Median age at first event (years) | 39.61 | 38.63 | 40.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Relationships between endpoints
↥Index endpoint: M13_ANKYLOSPON_STRICT – Ankylosing spondylitis, strict definition
GWS hits: 8
Loading Relationships table