Atrophic disorders of skin

L12_ATROPHICSKIN

skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L90
  • Cause of death: ICD-10 L90

2 out of 7 registries used, show all original rules.

4206

4. Check minimum number of events

None

4206

5. Include endpoints

4424

6. Filter based on genotype QC (FinnGen only)

4293

Control definitions (FinnGen only)

Control exclude L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L80-L99
Name in latin Morbositates atrophicae cutis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 35946 27772 8036
Only index persons 34204 26630 7574
Unadjusted period prevalence (%)
Whole population 0.67 0.80 0.22
Only index persons 0.83 0.98 0.29
Median age at first event (years)
Whole population 53.88 58.68 37.42
Only index persons 53.84 58.63 36.98

-FinnGen-

Key figures

All Female Male
Number of individuals 4293 3569 724
Unadjusted period prevalence (%) 1.36 1.55 0.40
Median age at first event (years) 57.40 58.96 49.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: L12_ATROPHICSKIN – Atrophic disorders of skin

GWS hits: 2

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