Tic disorders (more control exclusions)

KRA_PSY_TIC_EXMORE

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule None	-
2. Check conditions None
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F95 Hospital discharge: ICD-9 — 3072 Hospital discharge: ICD-8 — 30620 Cause of death: ICD-10 — F95 Cause of death: ICD-9 — 3072 Cause of death: ICD-8 — 30620 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude KRA_PSY_ANYMENTAL

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F90-F98

Name in latin Perturbationes ticiformes

NAME	KRA_PSY_TIC_EXMORE
CONTROL_EXCLUDE	KRA_PSY_ANYMENTAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F95
HD_ICD_9	3072
HD_ICD_8	30620
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F95
COD_ICD_9	3072
COD_ICD_8	30620
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Tic disorders (more control exclusions) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Tic disorders

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All

Female

Male

Number of individuals

Whole population

12184

3427

8742

Only index persons

9944

2898

7046

Unadjusted period prevalence (%)

Whole population

0.20

0.10

0.24

Only index persons

0.22

0.11

0.27

Median age at first event (years)

Whole population

9.93

10.84

9.52

Only index persons

10.81

12.11

10.28

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	365	182	183
Unadjusted period prevalence (%)	0.09	0.08	0.10
Median age at first event (years)	14.62	17.26	11.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry
?

Hazard ratios

Measures the association between a covariate and the risk of death. Hazard ratios greater than 1 indicate that the covariate is associated with an increased risk of death whereas hazard ratios smaller than 1 indicate the opposite. Hazard ratios are presented with 95 % confidence intervals and p-values.

Mortality risk

Estimates the N-year risk of death for a person of a specific age having the endpoint. See Documentation for more details.

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Relationships between endpoints
?

Case overlap:

The overlap between the endpoint cases is shown for the whole FinRegistry (FR) data and FinnGen (FG) data. Please note, that these values are independent of the shown analysis results. The first (upper) value shows the number of cases having both endpoints. The second (lower) value shows the Jaccard index: (intersect of cases, i.e. the number of individuals having both endpoints) / (union of cases, i.e. the number of individuals having one or both of the endpoints) * 100.

Survival analysis:

Hazard ratios (HR) with 95% confidence intervals are shown for cases in the FinRegistry data where the onset of the selected endpoint occurred first. Results with statistically significant Bonferroni corrected p-values are indicated by . See Documentation for details.

Extremity box plot compares the hazard ratio (HR) for a single survival analysis with the distribution of HRs across all the survival analyses for the same disease endpoint.

This plot shows the distribution of binned HRs:

X axis: percentile distribution of HRs, from 0 to 1.

light-grey zone: 95% of all HRs are within this interval

grey zone: 50% of all HRs are within this interval

dark vertical line: median of HRs

black dot: HR for a specific survival analysis

If our endpoint of interest is A and we are interested in the survival analysis of A → B (solid dot), we compute the distribution of HRs of type → B. If the HR for A → B lies inside the distribution of HRs for * → B , this indicates a not too unsurprising association.

Genetic correlations:

rg shows the pairwise genetic correlation between the endpoints in FinnGen together with 95% confidence intervals. Genetic correlations are truncated to be between 1.0 and -1.0. Results with statistically significant p-values (threshold 1x10^-6) are indicated by *. Extremity box plot compares the genetic correlation (rg) for a single genetic correlation analysis with the distribution of rg's across all the genetic correlation analyses for the same disease endpoint.

Genetic signals:

Hits show the number of genome-wide significant hits and Coloc hits show the colocal genome-wide significant hits between the endpoints in the FinnGen data.

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Index endpoint: KRA_PSY_TIC_EXMORE – Tic disorders (more control exclusions)

GWS hits: 1

Loading Relationships table

Tic disorders (more control exclusions)

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

Number of individuals

Period prevalence

Median age at first event

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Hazard ratios

Mortality risk

Case overlap:

Survival analysis:

Genetic correlations:

Genetic signals: