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Stroke, excluding SAH

DOID EFO Endpoint Browser PheWeb

I9_STR

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I61, I63, I64
  • Hospital discharge: ICD-9 — 431|4330A|4331A|4339A|4340A|4341A|4349A|436
  • Hospital discharge: ICD-8 — 431|433|434|436
  • Hospital discharge: excluded ICD-10 — I63.6
  • Hospital discharge: excluded ICD-8 — 43101|43191
  • Cause of death: ICD-10 — I61, I63, I64
  • Cause of death: ICD-9 — 431|4330A|4331A|4339A|4340A|4341A|4349A|436
  • Cause of death: ICD-8 — 431|433|434|436
  • Cause of death: excluded ICD-10 — I63.6
  • Cause of death: excluded ICD-8 — 43101|43191

2 out of 7 registries used, show all original rules.

28482

4. Check minimum number of events

None

28482

5. Include endpoints

None

28482

6. Filter based on genotype QC (FinnGen only)

27496

Control definitions (FinnGen only)

Control exclude I9_STR_EXH, I9_TIA

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 442894 213432 221786
Only index persons 272780 134306 138474
Unadjusted period prevalence (%)
Whole population 6.19 6.11 6.20
Only index persons 5.11 4.94 5.29
Median age at first event (years)
Whole population 72.64 76.00 69.48
Only index persons 71.92 75.42 68.53

-FinnGen-

Key figures

All Female Male
Number of individuals 27496 10488 17008
Unadjusted period prevalence (%) 7.52 4.55 9.35
Median age at first event (years) 68.98 68.74 69.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_STR – Stroke, excluding SAH

GWS hits: 5

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