Occlusion and stenosis of arteries, not leading to stroke

I9_STENOSIS

intracranial embolism: Blocking of a blood vessel in the skull by an embolus which can be a blood clot (thrombus) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with heart diseases. Other non-cardiac sources of emboli are usually associated with vascular diseases.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I66
  • Hospital discharge: ICD-9 4330X|4331X|4339X
  • Cause of death: ICD-10 I66
  • Cause of death: ICD-9 4330X|4331X|4339X

2 out of 7 registries used, show all original rules.

458

4. Check minimum number of events

None

458

5. Include endpoints

None

458

6. Filter based on genotype QC (FinnGen only)

440

Control definitions (FinnGen only)

Control exclude I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I60-I69
Name in latin Occlusio sive stenosis arteriarum cerebralium sine infarctu

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7018 2849 3990
Only index persons 3710 1691 2019
Unadjusted period prevalence (%)
Whole population 0.10 0.08 0.11
Only index persons 0.07 0.06 0.08
Median age at first event (years)
Whole population 67.81 70.75 65.76
Only index persons 65.92 68.76 63.54

-FinnGen-

Key figures

All Female Male
Number of individuals 440 131 309
Unadjusted period prevalence (%) 0.14 0.06 0.17
Median age at first event (years) 62.52 62.42 62.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: I9_STENOSIS – Occlusion and stenosis of arteries, not leading to stroke

GWS hits: 1

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