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Progressive vascular leukoencephalopathy

DOID EFO Endpoint Browser PheWeb

I9_PROGVASC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I67.3
  • Cause of death: ICD-10 — I67.3

2 out of 7 registries used, show all original rules.

797

4. Check minimum number of events

None

797

5. Include endpoints

None

797

6. Filter based on genotype QC (FinnGen only)

772

Control definitions (FinnGen only)

Control exclude I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I67
Name in latin Leucoencephalopathia vascularis progressiva

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8396 4988 3358
Only index persons 7636 4604 3032
Unadjusted period prevalence (%)
Whole population 0.12 0.14 0.09
Only index persons 0.15 0.17 0.12
Median age at first event (years)
Whole population 80.45 81.63 78.75
Only index persons 80.80 81.89 79.13

-FinnGen-

Key figures

All Female Male
Number of individuals 772 381 391
Unadjusted period prevalence (%) 0.19 0.17 0.22
Median age at first event (years) 79.16 79.61 78.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_PROGVASC – Progressive vascular leukoencephalopathy

GWS hits: -

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