Hypertrophic cardiomyopathy

I9_HYPERTROCARDMYOP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

1172

4. Check minimum number of events

None

1172

5. Include endpoints

None

1172

6. Filter based on genotype QC (FinnGen only)

1125

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9589 3813 5697
Only index persons 8026 3216 4810
Unadjusted period prevalence (%)
Whole population 0.14 0.11 0.16
Only index persons 0.16 0.12 0.18
Median age at first event (years)
Whole population 62.13 65.75 59.66
Only index persons 61.60 64.96 59.35

-FinnGen-

Key figures

All Female Male
Number of individuals 1125 455 670
Unadjusted period prevalence (%) 0.30 0.20 0.37
Median age at first event (years) 60.24 58.63 61.33

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: I9_HYPERTROCARDMYOP – Hypertrophic cardiomyopathy

GWS hits: 21

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