Hypertrophic cardiomyopathy

I9_HYPERTROCARDMYOP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	429209
1. Apply sex-specific rule None	429209
2. Check conditions None	429209
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I42.1, I42.2 Cause of death: ICD-10 — I42.1, I42.2 2 out of 7 registries used, show all original rules.	1172
4. Check minimum number of events None	1172
5. Include endpoints None	1172
6. Filter based on genotype QC (FinnGen only)	1125

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF3

NAME	I9_HYPERTROCARDMYOP
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I42[1-2]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I42[1-2]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Hypertrophic cardiomyopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Heart failure and hypertrophic cardiomyopathy

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	9589	3813	5697
Only index persons	8026	3216	4810
Unadjusted period prevalence (%)
Whole population	0.14	0.11	0.16
Only index persons	0.16	0.12	0.18
Median age at first event (years)
Whole population	62.13	65.75	59.66
Only index persons	61.60	64.96	59.35

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1125	455	670
Unadjusted period prevalence (%)	0.30	0.20	0.37
Median age at first event (years)	60.24	58.63	61.33

≡ Risteys

FR+FG R10

FinnGen Risteys R10

FinnGen Risteys R9

FinnGen Risteys R8

FinnGen Risteys R7

FinnGen Risteys R6

FinnGen Risteys R5

FinnGen Risteys R4

FinnGen Risteys R3

Hypertrophic cardiomyopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Hypertrophic cardiomyopathy (I9_HYPERTROCARDMYOP)

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints