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Coronary atherosclerosis

DOID EFO Endpoint Browser PheWeb

I9_CORATHER

heart aneurysm: A localized bulging or dilatation in the muscle wall of a heart (myocardium), usually in the left ventricle. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are hematoma caused by myocardial rupture.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I24, I25, T82.2, Z95.1
  • Hospital discharge: ICD-9 — 414|9960A
  • Hospital discharge: ICD-8 — 414
  • Hospital discharge: excluded ICD-10 — I25.3
  • Cause of death: ICD-10 — I24, I25, T82.2, Z95.1
  • Cause of death: ICD-9 — 414|9960A
  • Cause of death: ICD-8 — 414
  • Cause of death: excluded ICD-10 — I25.3

2 out of 7 registries used, show all original rules.

53252

4. Check minimum number of events

None

53252

5. Include endpoints

None

53252

6. Filter based on genotype QC (FinnGen only)

51589

Control definitions (FinnGen only)

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 657584 279386 367876
Only index persons 436363 184909 251454
Unadjusted period prevalence (%)
Whole population 9.32 8.00 10.28
Only index persons 8.41 6.80 9.60
Median age at first event (years)
Whole population 72.88 77.44 69.41
Only index persons 71.32 76.17 67.74

-FinnGen-

Key figures

All Female Male
Number of individuals 51589 15572 36017
Unadjusted period prevalence (%) 15.87 6.76 19.81
Median age at first event (years) 68.32 69.40 67.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_CORATHER – Coronary atherosclerosis

GWS hits: 95

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