Cardiomyopathy, Hypertrophic obstructive

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I42.1
  • Hospital discharge: ICD-9 4251A
  • Hospital discharge: ICD-8 42500
  • Cause of death: ICD-10 I42.1
  • Cause of death: ICD-9 4251A
  • Cause of death: ICD-8 42500

2 out of 7 registries used, show all original rules.

574

4. Check minimum number of events

None

574

5. Include endpoints

None

574

6. Filter based on genotype QC (FinnGen only)

553

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF5
Parent code in ICD-10 I42
Name in latin Cardiomyopathia hypertrophica obstructiva

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5095 2157 2870
Only index persons 3542 1521 2021
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.07 0.06 0.08
Median age at first event (years)
Whole population 59.89 63.64 56.99
Only index persons 58.98 62.46 56.35

-FinnGen-

Key figures

All Female Male
Number of individuals 553 220 333
Unadjusted period prevalence (%) 0.15 0.10 0.18
Median age at first event (years) 58.43 58.34 58.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive

GWS hits: 14

loading spinner Loading Relationships table