Atherosclerosis, excluding cerebral, coronary and PAD

I9_ATHSCLE

atherosclerosis: Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I70
  • Hospital discharge: ICD-9 440|4370|4371X
  • Hospital discharge: ICD-8 440
  • Cause of death: ICD-10 I70
  • Cause of death: ICD-9 440|4370|4371X
  • Cause of death: ICD-8 440

2 out of 7 registries used, show all original rules.

16730

4. Check minimum number of events

None

16730

5. Include endpoints

None

16730

6. Filter based on genotype QC (FinnGen only)

16243

Control definitions (FinnGen only)

Control exclude I9_DOAAC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I70-I79
Name in latin Atherosclerosis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 196160 81610 110955
Only index persons 123818 53401 70417
Unadjusted period prevalence (%)
Whole population 2.79 2.34 3.10
Only index persons 2.38 1.96 2.69
Median age at first event (years)
Whole population 72.94 77.00 70.02
Only index persons 72.49 76.43 69.50

-FinnGen-

Key figures

All Female Male
Number of individuals 16243 4769 11474
Unadjusted period prevalence (%) 5.07 2.07 6.31
Median age at first event (years) 69.39 69.85 69.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Relationships between endpoints

Index endpoint: I9_ATHSCLE – Atherosclerosis, excluding cerebral, coronary and PAD

GWS hits: 18

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