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Angina pectoris

DOID EFO Endpoint Browser PheWeb

I9_ANGINA

Prinzmetal's angina: a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. It is caused by vasospasm, a narrowing of the coronary arteries caused by contraction of the smooth muscle tissue in the vessel walls rather than directly by atherosclerosis (buildup of fatty plaque and hardening of the arteries). For a portion of patients Prinzmetal's angina may be a manifestation of vasospastic disorder and is associated with migraine, Raynaud's phenomenon or aspirin-induced asthma.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I20
  • Hospital discharge: ICD-9 — 413|411[0-1]
  • Hospital discharge: ICD-8 — 413
  • Cause of death: ICD-10 — I20
  • Cause of death: ICD-9 — 413|411[0-1]
  • Cause of death: ICD-8 — 413

2 out of 7 registries used, show all original rules.

38139

4. Check minimum number of events

None

38139

5. Include endpoints

None

38139

6. Filter based on genotype QC (FinnGen only)

36874

Control definitions (FinnGen only)

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I20-I25
Name in latin Angina pectoris

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 430780 181814 242255
Only index persons 286312 121758 164554
Unadjusted period prevalence (%)
Whole population 6.11 5.21 6.77
Only index persons 5.51 4.48 6.28
Median age at first event (years)
Whole population 66.20 69.67 63.56
Only index persons 64.60 67.84 62.21

-FinnGen-

Key figures

All Female Male
Number of individuals 36874 12258 24616
Unadjusted period prevalence (%) 10.81 5.32 13.54
Median age at first event (years) 63.32 64.29 62.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: I9_ANGINA – Angina pectoris

GWS hits: 76

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