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Cholesteatoma of middle ear

DOID EFO Endpoint Browser PheWeb

H8_CHOLEASTOMA

cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H71
  • Hospital discharge: ICD-9 — 3853
  • Hospital discharge: ICD-8 — 38700
  • Cause of death: ICD-10 — H71
  • Cause of death: ICD-9 — 3853
  • Cause of death: ICD-8 — 38700

2 out of 7 registries used, show all original rules.

1627

4. Check minimum number of events

None

1627

5. Include endpoints

None

1627

6. Filter based on genotype QC (FinnGen only)

1548

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Cholesteatoma auris mediae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17391 7390 9876
Only index persons 15196 6641 8555
Unadjusted period prevalence (%)
Whole population 0.25 0.21 0.28
Only index persons 0.29 0.24 0.33
Median age at first event (years)
Whole population 46.07 49.35 43.53
Only index persons 44.52 48.24 41.62

-FinnGen-

Key figures

All Female Male
Number of individuals 1548 674 874
Unadjusted period prevalence (%) 0.40 0.29 0.48
Median age at first event (years) 49.23 47.98 50.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear

GWS hits: 2

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