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Primary open-angle glaucoma, strict

DOID EFO Endpoint Browser PheWeb

H7_GLAUCOMA_POAG

open-angle glaucoma: Chronic outflow obstruction of the eye's drainage canals that can lead to increased internal eye pressure and optic nerve damage.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H40.1
  • Hospital discharge: ICD-9 — 3651[A|C|E|X]
  • Hospital discharge: ICD-8 — 37510
  • Hospital discharge: excluded ICD-10 — H40.10, H40.12
  • Cause of death: ICD-10 — H40.1
  • Cause of death: ICD-9 — 3651[A|C|E|X]
  • Cause of death: ICD-8 — 37510
  • Cause of death: excluded ICD-10 — H40.10, H40.12

2 out of 7 registries used, show all original rules.

8810

4. Check minimum number of events

None

8810

5. Include endpoints

None

8810

6. Filter based on genotype QC (FinnGen only)

8529

Control definitions (FinnGen only)

Control exclude H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF4
Parent code in ICD-10 H40
Name in latin Glaucoma simplex primarium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 97098 58563 37736
Only index persons 79574 48741 30833
Unadjusted period prevalence (%)
Whole population 1.43 1.68 1.05
Only index persons 1.55 1.79 1.18
Median age at first event (years)
Whole population 71.03 71.96 69.63
Only index persons 70.76 71.66 69.33

-FinnGen-

Key figures

All Female Male
Number of individuals 8529 4652 3877
Unadjusted period prevalence (%) 2.07 2.02 2.13
Median age at first event (years) 69.39 68.97 69.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: H7_GLAUCOMA_POAG – Primary open-angle glaucoma, strict

GWS hits: 48

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