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Background retinopathy and retinal vascular changes

DOID EFO Endpoint Browser PheWeb

H7_BCKRNDRETINOPAT

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H35.0
  • Hospital discharge: ICD-9 — 3621|3624A
  • Hospital discharge: ICD-8 — 36701|37705|37709|37712
  • Cause of death: ICD-10 — H35.0
  • Cause of death: ICD-9 — 3621|3624A
  • Cause of death: ICD-8 — 36701|37705|37709|37712

2 out of 7 registries used, show all original rules.

600

4. Check minimum number of events

None

600

5. Include endpoints

None

600

6. Filter based on genotype QC (FinnGen only)

576

Control definitions (FinnGen only)

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H35
Name in latin Retinopathia recessualis et commutationes vasculares retinae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6024 2953 3018
Only index persons 5178 2570 2608
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.08
Only index persons 0.10 0.09 0.10
Median age at first event (years)
Whole population 59.07 63.57 54.72
Only index persons 58.11 62.71 53.57

-FinnGen-

Key figures

All Female Male
Number of individuals 576 275 301
Unadjusted period prevalence (%) 0.14 0.12 0.17
Median age at first event (years) 57.04 56.76 57.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: H7_BCKRNDRETINOPAT – Background retinopathy and retinal vascular changes

GWS hits: 1

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